Enzyme Mechanism Ontology

Last uploaded: September 23, 2015
Preferred Name

Biological Assembly

Definitions

This can be unknown if there is no available data, although the entry should state that it is unknown and will be formed from a series of identifed polymers (i.e. Uniprot identifiers), although the exact composition and arrnagement isn't known.

ID

http://www.semanticweb.org/ontologies/2011/1/14/EMO.owl/EMO_00126

comment

This can be unknown if there is no available data, although the entry should state that it is unknown and will be formed from a series of identifed polymers (i.e. Uniprot identifiers), although the exact composition and arrnagement isn't known.

description

This can be a single chain, or a complex assembly of multiple identical or non-identical chains. For example, the biological unit of hemoglobin includes two alpha chains and two beta chains, making it a tetrameric α2β2 structure. When a biological unit contains multiple chains that have co-evolved to bind to each other, it may also be referred to as a specific oligomer. It should also be noted that a single enzyme might have multiple different biological assemblies, and different conditions may cause different assemblies so there may be more than one functional form (biological unit) that includes a given protein chain. For example, phosphorylation or dephosphorylation by protein kinases or phosphatases often change the affinities between proteins, and hence their quaternary assemblies.Published macromolecular structure data files (Atomic coordinate files, often in the PDB file format) contain the Asymmetric Unit, which may be identical with the biological unit, or only a portion of it, or may contain multiple biological units. When publishing a macromolecular structure, the authors may elect to specify the biological unit. In the PDB file format, this is done in REMARK 350.

contributor

Julius O. B. Jacobsen

Gemma L. Holliday

definition

The quaternary structure of a protein that is believed to be the functional form of the molecule.

label

Biological Assembly

prefLabel

Biological Assembly

subClassOf

http://www.w3.org/2002/07/owl#Thing

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