Human Interaction Network Ontology

Last uploaded: June 27, 2014
Preferred Name

phenylalanine + oxaloacetate => phenylpyruvate + aspartate [CCBL1]

Definitions

Reviewed: Jassal, B, 2012-03-16 Edited: D'Eustachio, P, 2012-03-16 Authored: D'Eustachio, P, 2012-03-04 CCBL1 (KAT1) catalyzes the reaction of phenylalanine and oxaloacetate to form keto-phenylpyruvate and aspartate. The active form of CCBL1 is a homodimer with one molecule of pyridoxal phosphate bound to each monomer (Rossi et al. 2004). CCBL1 (KAT1) acts on phenylalanine and kynurenine with comparable efficiencies (Han et al. 2004), consistent with the idea that when phenylalanine levels are elevated CCBL1 (KAT1) activity could be a major source of phenylpyruvate. Oxaloacetate is one of several 2-oxoacids that function efficiently in CCBL1-mediated transamination (Han et al. 2004). Notably, neither tyrosine aminotransferase (Sivaraman and Kirsch 2006) nor glutamate-oxaloacetate aminotransferase (Cammarata and Cohen 1951) acts on phenylalanine.

ID

http://purl.obolibrary.org/obo/HINO_0008199

comment

Reviewed: Jassal, B, 2012-03-16

Edited: D'Eustachio, P, 2012-03-16

Authored: D'Eustachio, P, 2012-03-04

CCBL1 (KAT1) catalyzes the reaction of phenylalanine and oxaloacetate to form keto-phenylpyruvate and aspartate. The active form of CCBL1 is a homodimer with one molecule of pyridoxal phosphate bound to each monomer (Rossi et al. 2004). CCBL1 (KAT1) acts on phenylalanine and kynurenine with comparable efficiencies (Han et al. 2004), consistent with the idea that when phenylalanine levels are elevated CCBL1 (KAT1) activity could be a major source of phenylpyruvate. Oxaloacetate is one of several 2-oxoacids that function efficiently in CCBL1-mediated transamination (Han et al. 2004). Notably, neither tyrosine aminotransferase (Sivaraman and Kirsch 2006) nor glutamate-oxaloacetate aminotransferase (Cammarata and Cohen 1951) acts on phenylalanine.

definition source

Reactome, http://www.reactome.org

Pubmed16640556

Pubmed14907689

Pubmed15364907

Pubmed15606768

has input

http://purl.obolibrary.org/obo/CHEBI_30744

http://purl.obolibrary.org/obo/CHEBI_17295

has output

http://purl.obolibrary.org/obo/CHEBI_18005

http://purl.obolibrary.org/obo/CHEBI_17053

label

phenylalanine + oxaloacetate => phenylpyruvate + aspartate [CCBL1]

prefixIRI

HINO:0008199

prefLabel

phenylalanine + oxaloacetate => phenylpyruvate + aspartate [CCBL1]

seeAlso

Reactome Database ID Release 432160461

ReactomeREACT_121130

subClassOf

http://purl.obolibrary.org/obo/INO_0000040

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