Human Interaction Network Ontology

Last uploaded: June 27, 2014
Preferred Name

phenylpyruvate + NADH + H+ => phenyllactate + NAD+

Definitions

Reviewed: Jassal, B, 2012-03-16 The ability of human lactate dehydrogenase to catalyze the reaction of phenylalanine with NADH + H+ to form phenyllactate and NAD+ is inferred from the properties of bovine heart lactate dehydrogenase (Meister 1951). As these studies were carried out only on the one bovine isoform, the reaction is inferred only for the corresponding human isoform. The reaction rate measured for bovine LDHB acting on phenylpyruvate is approximately 2% of its rate on pyruvate, but could yield appreciable amounts of phenyllactate under conditions of high phenylpyruvate concentration. Edited: D'Eustachio, P, 2012-03-16 Authored: D'Eustachio, P, 2012-03-04

ID

http://purl.obolibrary.org/obo/HINO_0008202

comment

Reviewed: Jassal, B, 2012-03-16

The ability of human lactate dehydrogenase to catalyze the reaction of phenylalanine with NADH + H+ to form phenyllactate and NAD+ is inferred from the properties of bovine heart lactate dehydrogenase (Meister 1951). As these studies were carried out only on the one bovine isoform, the reaction is inferred only for the corresponding human isoform. The reaction rate measured for bovine LDHB acting on phenylpyruvate is approximately 2% of its rate on pyruvate, but could yield appreciable amounts of phenyllactate under conditions of high phenylpyruvate concentration.

Edited: D'Eustachio, P, 2012-03-16

Authored: D'Eustachio, P, 2012-03-04

definition source

Reactome, http://www.reactome.org

Pubmed15421980

has input

http://purl.obolibrary.org/obo/CHEBI_15378

http://purl.obolibrary.org/obo/CHEBI_18005

http://purl.obolibrary.org/obo/CHEBI_16908

has output

http://purl.obolibrary.org/obo/CHEBI_8100

http://purl.obolibrary.org/obo/CHEBI_15846

label

phenylpyruvate + NADH + H+ => phenyllactate + NAD+

prefixIRI

HINO:0008202

prefLabel

phenylpyruvate + NADH + H+ => phenyllactate + NAD+

seeAlso

ReactomeREACT_121215

Reactome Database ID Release 432160489

subClassOf

http://purl.obolibrary.org/obo/INO_0000040

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