Human Interaction Network Ontology

Last uploaded: June 27, 2014
Preferred Name

Latent infection of Homo sapiens with Mycobacterium tuberculosis

Definitions

Infection by <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) is soon countered by the host's immune system, the organism is however almost never eradicated; ten per cent of infections will develop into "open tuberculosis", while the other ninety per cent become "latent", a state that can persist for decades until loss of immune control. A third of the world's population is estimated to harbour latent tuberculosis. Latent infection involves the bacterium being internalized by macrophages where it stops and counters the innate immune answer (Russell 2011, Russell et al. 2010). When a status-quo is reached, <i>Mtb</i> enters a non-replicating persistent state (Barry et al. 2009, Boshoff & Barry 2005). Edited: Jassal, B, 2011-02-28 Authored: Stephan, R, 2011-01-10 Reviewed: Warner, D, 2012-04-30

ID

http://purl.obolibrary.org/obo/HINO_0015996

comment

Infection by Mycobacterium tuberculosis (Mtb) is soon countered by the host's immune system, the organism is however almost never eradicated; ten per cent of infections will develop into "open tuberculosis", while the other ninety per cent become "latent", a state that can persist for decades until loss of immune control. A third of the world's population is estimated to harbour latent tuberculosis. Latent infection involves the bacterium being internalized by macrophages where it stops and counters the innate immune answer (Russell 2011, Russell et al. 2010). When a status-quo is reached, Mtb enters a non-replicating persistent state (Barry et al. 2009, Boshoff & Barry 2005).

Edited: Jassal, B, 2011-02-28

Authored: Stephan, R, 2011-01-10

Reviewed: Warner, D, 2012-04-30

definition source

Reactome, http://www.reactome.org

Pubmed15608701

Pubmed20466922

Pubmed19855401

Pubmed21349098

label

Latent infection of Homo sapiens with Mycobacterium tuberculosis

located_in

http://purl.obolibrary.org/obo/NCBITaxon_9606

prefixIRI

HINO:0015996

prefLabel

Latent infection of Homo sapiens with Mycobacterium tuberculosis

seeAlso

ReactomeREACT_121237

Reactome Database ID Release 431222352

GENE ONTOLOGYGO:0051701

has_part

http://purl.obolibrary.org/obo/HINO_0015999

http://purl.obolibrary.org/obo/HINO_0015986

subClassOf

http://purl.obolibrary.org/obo/INO_0000021

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